Are Sodium-Glucose Cotransporter-2 Inhibitors the Cherry on Top of Cardio-Oncology Care?
Cardiovasc Drugs Ther
; 2024 Jul 03.
Article
em En
| MEDLINE
| ID: mdl-38958827
ABSTRACT
The increasing aging of the population combined with improvements in cancer detection and care has significantly improved the survival and quality of life of cancer patients. These benefits are hampered by the increase of cardiovascular diseases being heart failure the most frequent manifestation of cardiotoxicity and becoming the major cause of morbidity and mortality among cancer survivor. Current strategies to prevent cardiotoxicity involves different approaches such as optimal management of CV risk factors, use of statins and/or neurohormonal medications, and, in some cases, even the use of chelating agents. As a class, SGLT2-i have revolutionized the therapeutic horizon of HF patients independently of their ejection fraction or glycemic status. There is an abundance of data from translational and observational clinical studies supporting a potential beneficial role of SGLT2-i in mitigating the cardiotoxic effects of cancer patients receiving anthracyclines. These findings underscore the need for more robust clinical trials to investigate the effect on cardiovascular outcomes of the prophylactic SGLT2-i treatment in patients undergoing cancer treatment.
ACEi angiotensin-converting enzyme inhibitors; BBbeta blockers; CTRCD cancer therapy related cardiac dysfunction; CVD cardiovascular disease; DMdiabetes mellitus; GDMT guideline-directed medical therapy; HFheart failure; LV left ventricle; LVEF left ventricular ejection fraction; SGLT2 sodium-glucose cotransporter 2; SGLT2-i SGLT2 inhibitors
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article