Venetoclax resistance in acute lymphoblastic leukemia is characterized by increased mitochondrial activity and can be overcome by co-targeting oxidative phosphorylation.

Enzenmüller, Stefanie; Niedermayer, Alexandra; Seyfried, Felix; Muench, Vera; Tews, Daniel; Rupp, Ulrich; Tausch, Eugen; Groß, Alexander; Fischer-Posovszky, Pamela; Walther, Paul; Stilgenbauer, Stephan; Kestler, Hans A; Debatin, Klaus-Michael; Meyer, Lüder Hinrich

Enzenmüller, Stefanie; Niedermayer, Alexandra; Seyfried, Felix; Muench, Vera; Tews, Daniel; Rupp, Ulrich; Tausch, Eugen; Groß, Alexander; Fischer-Posovszky, Pamela; Walther, Paul; Stilgenbauer, Stephan; Kestler, Hans A; Debatin, Klaus-Michael; Meyer, Lüder Hinrich.

Afiliação

Enzenmüller S; Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany.
Niedermayer A; Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany.
Seyfried F; International Graduate School in Molecular Medicine, Ulm University, Ulm, Germany.
Muench V; Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany.
Tews D; Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany.
Rupp U; Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany.
Tausch E; Central Facility for Electron Microscopy, Ulm University, Ulm, Germany.
Groß A; Division of Chronic Lymphocytic Leukemia, Department of Internal Medicine III, University of Ulm, Ulm, Germany.
Fischer-Posovszky P; Institute of Medical Systems Biology, Ulm University, Ulm, Germany.
Walther P; Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany.
Stilgenbauer S; Central Facility for Electron Microscopy, Ulm University, Ulm, Germany.
Kestler HA; Division of Chronic Lymphocytic Leukemia, Department of Internal Medicine III, University of Ulm, Ulm, Germany.
Debatin KM; Institute of Medical Systems Biology, Ulm University, Ulm, Germany.
Meyer LH; Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany.

Cell Death Dis ; 15(7): 475, 2024 Jul 03.

Article em En | MEDLINE | ID: mdl-38961053

Assuntos

Compostos Bicíclicos Heterocíclicos com Pontes; Resistencia a Medicamentos Antineoplásicos; Mitocôndrias; Fosforilação Oxidativa; Leucemia-Linfoma Linfoblástico de Células Precursoras; Sulfonamidas; Compostos Bicíclicos Heterocíclicos com Pontes/farmacologia; Humanos; Fosforilação Oxidativa/efeitos dos fármacos; Mitocôndrias/metabolismo; Mitocôndrias/efeitos dos fármacos; Resistencia a Medicamentos Antineoplásicos/efeitos dos fármacos; Resistencia a Medicamentos Antineoplásicos/genética; Sulfonamidas/farmacologia; Leucemia-Linfoma Linfoblástico de Células Precursoras/metabolismo; Leucemia-Linfoma Linfoblástico de Células Precursoras/patologia; Leucemia-Linfoma Linfoblástico de Células Precursoras/tratamento farmacológico; Leucemia-Linfoma Linfoblástico de Células Precursoras/genética; Animais; Linhagem Celular Tumoral; Camundongos; Apoptose/efeitos dos fármacos; Antineoplásicos/farmacologia; Ensaios Antitumorais Modelo de Xenoenxerto; Proteínas Proto-Oncogênicas c-bcl-2/metabolismo; Proteínas Proto-Oncogênicas c-bcl-2/genética

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fosforilação Oxidativa / Sulfonamidas / Resistencia a Medicamentos Antineoplásicos / Compostos Bicíclicos Heterocíclicos com Pontes / Leucemia-Linfoma Linfoblástico de Células Precursoras / Mitocôndrias Limite: Animals / Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article

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