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The crosstalk between copper-induced oxidative stress and cuproptosis: a novel potential anticancer paradigm.
Vo, Thi Thuy Tien; Peng, Tzu-Yu; Nguyen, Thi Hong; Bui, Trang Ngoc Huyen; Wang, Ching-Shuen; Lee, Wei-Ju; Chen, Yuh-Lien; Wu, Yang-Che; Lee, I-Ta.
Afiliação
  • Vo TTT; Faculty of Dentistry, Nguyen Tat Thanh University, Ho Chi Minh City, 700000, Vietnam.
  • Peng TY; School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, 110301, Taiwan.
  • Nguyen TH; Faculty of Dentistry, Nguyen Tat Thanh University, Ho Chi Minh City, 700000, Vietnam.
  • Bui TNH; Faculty of Dentistry, Nguyen Tat Thanh University, Ho Chi Minh City, 700000, Vietnam.
  • Wang CS; School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, 110301, Taiwan.
  • Lee WJ; School of Food Safety, College of Nutrition, Taipei Medical University, Taipei, 110301, Taiwan.
  • Chen YL; Department of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taipei, 100233, Taiwan.
  • Wu YC; School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, 110301, Taiwan.
  • Lee IT; School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, 110301, Taiwan. itlee0128@tmu.edu.tw.
Cell Commun Signal ; 22(1): 353, 2024 Jul 05.
Article em En | MEDLINE | ID: mdl-38970072
ABSTRACT
Copper is a crucial trace element that plays a role in various pathophysiological processes in the human body. Copper also acts as a transition metal involved in redox reactions, contributing to the generation of reactive oxygen species (ROS). Under prolonged and increased ROS levels, oxidative stress occurs, which has been implicated in different types of regulated cell death. The recent discovery of cuproptosis, a copper-dependent regulated cell death pathway that is distinct from other known regulated cell death forms, has raised interest to researchers in the field of cancer therapy. Herein, the present work aims to outline the current understanding of cuproptosis, with an emphasis on its anticancer activities through the interplay with copper-induced oxidative stress, thereby providing new ideas for therapeutic approaches targeting modes of cell death in the future.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estresse Oxidativo / Cobre / Antineoplásicos Limite: Animals / Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estresse Oxidativo / Cobre / Antineoplásicos Limite: Animals / Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article