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UNCovering new causes of monogenic systemic lupus erythematosus.
Ellyard, Julia I; Gantier, Michael P.
Afiliação
  • Ellyard JI; Division of Immunology and Infectious Diseases, John Curtin School of Medical Research, The Australian National University, Acton, ACT, Australia.
  • Gantier MP; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC, Australia.
Immunol Cell Biol ; 102(8): 651-654, 2024 Sep.
Article em En | MEDLINE | ID: mdl-38981619
ABSTRACT
UNC93B1 is essential for the stability and endosomal trafficking of nucleic-acid sensing Toll-like receptors (TLRs) including TLR7 and TLR8. Increased TLR7 responses are associated with lupus autoimmunity in both mice and humans. In a recent article, Al-Azab et al. demonstrate the role of a variant of UNC93B1 (p.V117L) in the induction of pediatric systemic lupus erythematosus in patients and in mice through TLR7/8 hyperresponsiveness. They also highlight a potential role for the pharmacological inhibition of interleukin-1 receptor-associated kinase (IRAK) 1 and/or 4 in ameliorating disease.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptor 7 Toll-Like / Lúpus Eritematoso Sistêmico Limite: Animals / Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptor 7 Toll-Like / Lúpus Eritematoso Sistêmico Limite: Animals / Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article