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A pilot study of nintedanib in molecularly selected patients with advanced non-small cell lung cancer.
Auberle, Christine; Gao, Feng; Sloan, Mark; Morgensztern, Daniel; Winkler, Linda; Ward, Jeffrey P; Devarakonda, Siddhartha; Rearden, Timothy P; Govindan, Ramaswamy; Waqar, Saiama N.
Afiliação
  • Auberle C; Division of Oncology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
  • Gao F; Division of Oncology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
  • Sloan M; Division of Oncology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
  • Morgensztern D; Division of Oncology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
  • Winkler L; Division of Oncology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
  • Ward JP; Division of Oncology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
  • Devarakonda S; Medical Oncology, Swedish Cancer Institute First Hill, Seattle, WA, USA.
  • Rearden TP; Division of Oncology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
  • Govindan R; Division of Oncology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
  • Waqar SN; Division of Oncology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
J Thorac Dis ; 16(6): 3782-3793, 2024 Jun 30.
Article em En | MEDLINE | ID: mdl-38983151
ABSTRACT

Background:

Nintedanib is a small molecule tyrosine kinase inhibitor (TKI) targeting vascular endothelial growth factor receptor (VEGFR), platelet-derived growth factor receptor (PDGFR), and fibroblast growth factor receptor (FGFR). The purpose of the study was to evaluate the response rate for patients with advanced non-small cell lung cancer (NSCLC) with mutations in TP53, VEGFR1-3, PDGFR-A, PDGFR-B, and FGFR1-3 treated with nintedanib as part of an open-label, single-arm pilot study.

Methods:

Patients with advanced NSCLC previously treated with platinum-doublet chemotherapy with the above mutations were enrolled. Exclusion criteria included necrotic tumors with invasion of blood vessels, history of recent thromboembolic events, increased risk of bleeding or thrombosis, myocardial infarction, and weight loss >10% within past 6 months. Nintedanib was administered at a dose of 200 mg orally twice daily until disease progression or unacceptable toxicity. The primary endpoint was objective response rate (ORR) by Response Evaluation Criteria in Solid Tumors (RECIST) 1.1. Secondary endpoints included progression-free survival (PFS) and correlating outcomes with specific mutations. This study was registered with ClinicalTrials.gov, number NCT02299141.

Results:

Between 2015 and 2019, 20 patients were enrolled with a median age was 66 years, 15 (75%) were females, 15 (75%) had adenocarcinoma, and 17 patients had a TP53 mutation (85%). Seventeen (85%) had received prior immunotherapy and 11 (55%) had received at least three prior lines of systemic therapy. The ORR was 15% with three partial responses (PR), while 12 patients had stable disease (SD), with disease control rate (DCR) consisting of a PR and SD greater than or equal to 16 weeks of 65% (n=13). Median PFS was 4.3 months [95% confidence interval (CI) 1.8-7.9] and median overall survival (OS) was 11.3 months (95% CI 3.5-44.2). Three patients experienced prolonged clinical benefit from nintedanib, remaining on treatment for over 1 year and all three had a TP53 mutation and received prior immunotherapy. The most common adverse events of any grade included nausea (80%), fatigue (70%), diarrhea (60%), and anorexia (60%).

Conclusions:

In this pilot study in heavily pretreated and molecularly selected patients with metastatic NSCLC, nintedanib showed modest activity.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article