Copper-Mediated Decarboxylative Coupling of 3-Indoleacetic Acids with Sulfoxonium Ylides for the Synthesis of α-Acetoxyl Ketones.
Org Lett
; 26(28): 5940-5945, 2024 Jul 19.
Article
em En
| MEDLINE
| ID: mdl-38989672
ABSTRACT
The most convenient and direct method of synthesizing an α-acyloxy ketone is the reaction of a diazo compound with a carboxylic acid via O-H insertion. However, due to the limitations in preparing and storing diazo compounds, the application of this method is restricted. In this study, Cu(OAc)2-mediated (OAc = acetate) decarboxylative coupling reactions of 3-indoleacetic acids with sulfoxonium ylides were developed for use in rapidly synthesizing α-acetoxyl ketones. In this reaction, Cu(OAc)2 was not only used as an oxidant, but also as acetate ion source. Notably, when 5-methoxy-2-methyl-3-indoleacetic acid reacted with different sulfoxonium ylides, the corresponding products exhibited fluorescence, and furthermore, several products displayed antiproliferative activities against various human cancer cell lines.
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01-internacional
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MEDLINE
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article