Toxoplasma gondii infection supports the infiltration of T cells into brain tumors.
J Neuroimmunol
; 393: 578402, 2024 08 15.
Article
em En
| MEDLINE
| ID: mdl-38996717
ABSTRACT
Few T cells infiltrate into primary brain tumors, fundamentally hampering the effectiveness of immunotherapy. We hypothesized that Toxoplasma gondii, a microorganism that naturally elicits a Th1 response in the brain, can promote T cell infiltration into brain tumors despite their immune suppressive microenvironment. Using a mouse genetic model for medulloblastoma, we found that T. gondii infection induced the infiltration of activatable T cells into the tumor mass and led to myeloid cell reprogramming toward a T cell-supportive state, without causing severe health issues in mice. The study provides a concrete foundation for future studies to take advantage of the immune modulatory capacity of T. gondii to facilitate brain tumor immunotherapy.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Encefálicas
/
Toxoplasmose
Limite:
Animals
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article