Differentiation of regioisomeric N-alkylation of some indazoles and pyrazolopyridines by advanced NMR techniques.
Magn Reson Chem
; 2024 Jul 14.
Article
em En
| MEDLINE
| ID: mdl-39004604
ABSTRACT
Indazole scaffold have two interconvertible tautomeric forms. Regioselectivities were determined for N-benzylations and alkylation of some non-substituted and substituted indazoles, under basic conditions (K2CO3) in DMF. The ratio of regioisomers occurrence between N1N2 is almost equal. Their structures were established through a combination of NOESY and 1H-13C/15N HMBC NMR methods. Additionally, pyrazolo[3,4-b]pyridines have also three possible tautomeric forms; primarily 1H and 2H, with 7H isomers being rare. Pyrazolo[4,3-b]pyridines have only known two possible tautomeric forms so far; 1H and 2H.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article