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Histone demethylase PHF8 promotes prostate cancer metastasis via the E2F1-SNAI1 axis.
Wang, Ze; Tang, Peng; Xiao, Haiyang; Peng, Song; Chen, Jian; Wang, Yapeng; Xu, Jing; Yan, Qian; Zhang, Junying; Deng, Jie; Ma, Qiang; Zhu, Hailin; Luo, Weiming; Zhang, Dianzheng; Wang, Luofu; Qin, Jun; Lan, Weihua; Jiang, Jun; Liu, Qiuli.
Afiliação
  • Wang Z; Department of Urology, Daping Hospital, Army Medical University, Chongqing, PR China.
  • Tang P; Department of Urology, Daping Hospital, Army Medical University, Chongqing, PR China.
  • Xiao H; Department of Urology, Daping Hospital, Army Medical University, Chongqing, PR China.
  • Peng S; Department of Urology, Daping Hospital, Army Medical University, Chongqing, PR China.
  • Chen J; Department of Urology, Daping Hospital, Army Medical University, Chongqing, PR China.
  • Wang Y; Department of Urology, Daping Hospital, Army Medical University, Chongqing, PR China.
  • Xu J; Department of Urology, Daping Hospital, Army Medical University, Chongqing, PR China.
  • Yan Q; Department of Urology, Daping Hospital, Army Medical University, Chongqing, PR China.
  • Zhang J; Chongqing Key Laboratory of High Active Traditional Chinese Drug Delivery System, Chongqing Engineering Research Center of Pharmaceutical Sciences, Chongqing Medical and Pharmaceutical College, Chongqing, PR China.
  • Deng J; College of Pharmacy, Chongqing Medical University, Chongqing, PR China.
  • Ma Q; Department of Urology, Daping Hospital, Army Medical University, Chongqing, PR China.
  • Zhu H; Department of Urology, Daping Hospital, Army Medical University, Chongqing, PR China.
  • Luo W; Department of Urology, Daping Hospital, Army Medical University, Chongqing, PR China.
  • Zhang D; Department of Urology, Daping Hospital, Army Medical University, Chongqing, PR China.
  • Wang L; Department of Bio-Medical Sciences, Philadelphia College of Osteopathic Medicine, Philadelphia, PA, USA.
  • Qin J; Department of Urology, Daping Hospital, Army Medical University, Chongqing, PR China.
  • Lan W; CAS Key Laboratory of Tissue Microenvironment and Tumor, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Nutrition and Health Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, PR China.
  • Jiang J; Department of Urology, Daping Hospital, Army Medical University, Chongqing, PR China.
  • Liu Q; Department of Urology, Daping Hospital, Army Medical University, Chongqing, PR China.
J Pathol ; 2024 Jul 18.
Article em En | MEDLINE | ID: mdl-39022843
ABSTRACT
Metastasis is the primary culprit behind cancer-related fatalities in multiple cancer types, including prostate cancer. Despite great advances, the precise mechanisms underlying prostate cancer metastasis are far from complete. By using a transgenic mouse prostate cancer model (TRAMP) with and without Phf8 knockout, we have identified a crucial role of PHF8 in prostate cancer metastasis. By complexing with E2F1, PHF8 transcriptionally upregulates SNAI1 in a demethylation-dependent manner. The upregulated SNAI1 subsequently enhances epithelial-to-mesenchymal transition (EMT) and metastasis. Given the role of the abnormally activated PHF8/E2F1-SNAI1 axis in prostate cancer metastasis and poor prognosis, the levels of PHF8 or the activity of this axis could serve as biomarkers for prostate cancer metastasis. Moreover, targeting this axis could become a potential therapeutic strategy for prostate cancer treatment. © 2024 The Pathological Society of Great Britain and Ireland.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article