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The metabolic role of vitamin D in children's neurodevelopment: a network study.
De Marzio, Margherita; Lasky-Su, Jessica; Chu, Su H; Prince, Nicole; Litonjua, Augusto A; Weiss, Scott T; Kelly, Rachel S; Glass, Kimberly R.
Afiliação
  • De Marzio M; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. nhmdm@channing.harvard.edu.
  • Lasky-Su J; Department of Environmental Health, Harvard TH Chan School of Public Health, Boston, MA, USA. nhmdm@channing.harvard.edu.
  • Chu SH; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  • Prince N; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  • Litonjua AA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  • Weiss ST; Division of Pulmonary Medicine, Golisano Children's Hospital, University of Rochester, Rochester, NY, USA.
  • Kelly RS; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  • Glass KR; Department of Environmental Health, Harvard TH Chan School of Public Health, Boston, MA, USA.
Sci Rep ; 14(1): 16929, 2024 07 23.
Article em En | MEDLINE | ID: mdl-39043876
ABSTRACT
Neurodevelopmental disorders are rapidly increasing in prevalence and have been linked to various environmental risk factors. Mounting evidence suggests a potential role of vitamin D in child neurodevelopment, though the causal mechanisms remain largely unknown. Here, we investigate how vitamin D deficiency affects children's communication development, particularly in relation to Autism Spectrum Disorder (ASD). We do so by developing an integrative network approach that combines metabolomic profiles, clinical traits, and neurodevelopmental data from a pediatric cohort. Our results show that low levels of vitamin D are associated with changes in the metabolic networks of tryptophan, linoleic, and fatty acid metabolism. These changes correlate with distinct ASD-related phenotypes, including delayed communication skills and respiratory dysfunctions. Additionally, our analysis suggests the kynurenine and serotonin sub-pathways may mediate the effect of vitamin D on early life communication development. Altogether, our findings provide metabolome-wide insights into the potential of vitamin D as a therapeutic option for ASD and other communication disorders.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vitamina D / Deficiência de Vitamina D / Transtorno do Espectro Autista Limite: Child / Child, preschool / Female / Humans / Male Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vitamina D / Deficiência de Vitamina D / Transtorno do Espectro Autista Limite: Child / Child, preschool / Female / Humans / Male Idioma: En Ano de publicação: 2024 Tipo de documento: Article