Synthesis of chiral boranes via asymmetric insertion of carbenes into B-H bonds catalyzed by the rhodium(I) diene complex.
Chem Commun (Camb)
; 60(65): 8601-8604, 2024 Aug 09.
Article
em En
| MEDLINE
| ID: mdl-39045825
ABSTRACT
Molecules with chiral boron atoms have been scarcely studied due to limited synthetic access. Herein, we report a new method for their synthesis via asymmetric insertion of arydiazoacetates into the B-H bonds of prochiral carbene-boranes NHC-BH2R. The reaction is catalyzed by the rhodium(I) complex with the chiral diene ligand tBu2-TFB, which can be conveniently prepared by diastereoselective coordination of the racemic diene with (S-Salox)Rh(CO)2. The target boranes were typically obtained in 75-90% yields with 90-95% ee.
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01-internacional
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MEDLINE
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article