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Significant pituitary siderosis is common in transfusion-dependent sickle cell disease.
Vadivelan, Akhila; Doyle, Eamon K; Carson, Susan; Denton, Christopher; Veluswamy, Saranya; Hofstra, Thomas; Coates, Thomas D; Wood, John.
Afiliação
  • Vadivelan A; Division of Pediatric Hematology/Oncology, Department of Pediatrics, UCLA Mattel Children's Hospital, Los Angeles, CA.
  • Doyle EK; Department of Radiology, Children's Hospital of Los Angeles, Los Angeles, CA.
  • Carson S; Keck School of Medicine, University of Southern California, Los Angeles, CA.
  • Denton C; Section of Hematology, Department of Pediatrics, Cancer and Blood Disease Institute, Children's Hospital of Los Angeles, Los Angeles, CA.
  • Veluswamy S; Keck School of Medicine, University of Southern California, Los Angeles, CA.
  • Hofstra T; Section of Hematology, Department of Pediatrics, Cancer and Blood Disease Institute, Children's Hospital of Los Angeles, Los Angeles, CA.
  • Coates TD; Keck School of Medicine, University of Southern California, Los Angeles, CA.
  • Wood J; Section of Hematology, Department of Pediatrics, Cancer and Blood Disease Institute, Children's Hospital of Los Angeles, Los Angeles, CA.
Blood ; 144(13): 1457-1459, 2024 Sep 26.
Article em En | MEDLINE | ID: mdl-39046820
ABSTRACT
ABSTRACT Chronically transfused patients with sickle cell disease typically do not exhibit iron-mediated extrahepatic toxicity. However, we demonstrate that the pituitary gland is vulnerable to iron deposition, and it occurs regardless of other extrahepatic involvement. Severe pituitary siderosis is associated with early organ dysfunction.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Siderose / Anemia Falciforme Limite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Siderose / Anemia Falciforme Limite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2024 Tipo de documento: Article