The specific anti-hostility effect of lurasidone in patients with an acute exacerbation of schizophrenia: results of pooled post hoc analyses in adolescents and adults.
Int Clin Psychopharmacol
; 2024 Jul 22.
Article
em En
| MEDLINE
| ID: mdl-39052354
ABSTRACT
Symptoms of hostility in patients during acute exacerbations of schizophrenia have been associated with aggressive behavior. Data suggest that some second-generation antipsychotics have specific anti-hostility effects, independent of sedation and positive symptom improvement. Two post hoc analyses were performed to examine the efficacy of lurasidone for reducing hostility in patients with schizophrenia. One analysis pooled adults (Nâ
=â
1168) from 5 placebo-controlled, 6-week trials of lurasidone (40-160â
mg). Another analysis pooled younger patients (up to age 25â
years, Nâ
=â
427) from the adult studies and a similarly designed trial of lurasidone (40 or 80â
mg) in adolescent patients (13-17â
years old). The outcome measure was mean change in the hostility item (P7) of the Positive and Negative Syndrome Scale (PANSS). To address pseudospecificity, results were adjusted for positive symptom change and sedation. In adults with a baseline PANSS hostility score ≥2, significant improvement in hostility was observed for all doses with a dose-related increase in effect size (Cohen's d) lurasidone 40â
mgâ
=â
0.18, 80â
mgâ
=â
0.24, 120â
mgâ
=â
0.36, and 160â
mgâ
=â
0.53. The same dose-response pattern was observed for the more severe hostility subgroups (P7 ≥3, ≥4), and in the early-onset population. Results suggest that lurasidone has specific, dose-related anti-hostility effects.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article