Total Synthesis of Conjugation-Ready Hyperbranched Pentasaccharide of Clavibacter phaseoli VKM Ac-2641T by [Au]/[Ag] Catalysis.
Org Lett
; 2024 Jul 25.
Article
em En
| MEDLINE
| ID: mdl-39052645
ABSTRACT
Infections by Clavibacter spp. cause an economic burden to farmers. The components present in the cell wall glycopolymers (CWGs) are important for studying the host-pathogen interactions, colonization, and infection. A pentasaccharide containing a hyperbranched Ribf-, Galf-, and Manp- has recently been identified. Herein, we describe the first total synthesis of the conjugation-ready hyperbranched pentasaccharide of C. phaseoli VKM Ac-2641T using the [Au]/[Ag]-catalyzed glycosidation chemistry of ethynylcyclohexyl carbonate glycosyl donors. The pentasaccharide was synthesized in a highly convergent fashion from readily accessible monosaccharide building blocks.
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01-internacional
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MEDLINE
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article