Chronic intranasal oxytocin alleviates cognitive impairment and reverses oxytocin signaling upregulation in MK801-induced mice.
Psychoneuroendocrinology
; 168: 107138, 2024 Oct.
Article
em En
| MEDLINE
| ID: mdl-39068687
ABSTRACT
OBJECTIVE:
Cognitive impairment, especially impaired social cognition, is largely responsible for the deterioration of the social life of patients with schizophrenia (SZ). Oxytocin (OT) is a neuropeptide that offers promising therapy for SZ. This study aimed to explore whether OT could affect dizocilpine (MK801)-induced cognitive impairment and to investigate the effect of exogenous OT on the endogenous OT system in the hippocampus.METHODS:
The SZ mouse model was established by repeated administration of dizocilpine [MK801, 0.6â¯mg/kg, intraperitoneal (i.p.)], and then OT (6-60⯵g/kg, intranasal) or risperidone (0.3â¯mg/kg, i.p.) was administered to explore the effect of OT on cognitive impairment.RESULTS:
OT at a dose of 6⯵g/kg alleviated MK801-induced hyperactivity, sociability impairment, and spatial memory impairment. OT at a dose of 20 or 60⯵g/kg attenuated the hyperactivity and social novelty impairment. In MK801-injected mice, the compensatory upregulation of OT mRNA in the hippocampus was reversed by three OT doses, whereas 60⯵g/kg OT reversed the compensatory upregulation of CD38 protein expression.CONCLUSION:
OT alleviated cognitive impairment in the SZ mouse model to varying degrees, reversing the compensatory upregulation of OT signaling in the hippocampus.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Esquizofrenia
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Administração Intranasal
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Ocitocina
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Transdução de Sinais
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Regulação para Cima
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Maleato de Dizocilpina
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Modelos Animais de Doenças
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Disfunção Cognitiva
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Hipocampo
Limite:
Animals
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article