Angiogenic lipid-based drug delivery system (PhytoSolve) for treatment of a thin endometrium in animal model.
Tissue Cell
; 90: 102481, 2024 Oct.
Article
em En
| MEDLINE
| ID: mdl-39068689
ABSTRACT
Impaired vascular growth resulting from reduced vascular endothelial growth factor (VEGF) in the epithelial tissue of the glands is a primary cause of thin endometrium. Inducing angiogenesis offers a possible therapeutic strategy for this condition. This study aimed to develop a novel drug delivery system using S75 lipoid loaded with VEGF for thin endometrium therapy. The formulation of PhytoSolve consisted of a combination of lipid S75, glycerol, and MCT oil, which was prepared utilizing a probe sonicator. Female NMRI mice (n=30) were divided into six groups control, sham, thin endometrial model, VEGF treatment, PhytoSolve treatment, and VEGF/PhytoSolve treatment. A thin endometrial model was induced by injecting 95â¯% ethanol. After the treatment period, tissue samples were collected to assess the endometrial thickness-the mean particle size of the PhytoSolve formulation measured 67.57±7.07â¯nm. Approximately 40â¯% of the loaded VEGF was released within the first 24â¯hours, followed by a sustained release rate of 10-20â¯% daily. The PhytoSolve group containing VEGF exhibited significantly increased endometrial thickness compared to the VEGF group (P<0.05). S75 lipoid-based PhytoSolve loaded with VEGF effectively promoted blood vessel formation. The combination of PhytoSolve S75 and VEGF holds promise for developing a biocompatible drug delivery system with therapeutic potential for treating thin endometrium and various other biomedical applications.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sistemas de Liberação de Medicamentos
/
Fator A de Crescimento do Endotélio Vascular
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Endométrio
Limite:
Animals
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article