Validation of Lung Ultrasound for COVID-19 Prognostication in an International Multicenter Cohort Study.
J Infect Dis
; 2024 Jul 29.
Article
em En
| MEDLINE
| ID: mdl-39073767
ABSTRACT
BACKGROUND:
Despite many studies evaluating lung ultrasound (LUS) for COVID-19 prognostication, the generalizability and utility across clinical settings is uncertain.METHODS:
Adults (≥18 years of age) with COVID-19 were enrolled at two military hospitals, an emergency department, home visits, and a homeless shelter in the United States, and in a referral hospital in Uganda. Participants had a 12-zone LUS scan performed at time of enrollment and clips were read off-site. The primary outcome was progression to higher level of care after the ultrasound scan. We calculated the cross-validated area under the curve for the validation cohort for individual LUS features.RESULTS:
We enrolled 191 participants with COVID-19 were enrolled (57.9% female, median age 45.0 years, interquartile range [IQR] 31.5, 58.0). Nine participants clinically deteriorated. The top predictors of worsening disease in the validation cohort measured by cross-validated area under the curve (cvAUC) were B-lines (0.88, 95% confidence interval [CI] 0.87, 0.90), discrete B-lines (0.87, 95% CI 0.85, 0.88), oxygen saturation (0.82, 95% CI0.81, 0.84), and A-lines (0.80, 95% CI 0.78, 0.81).CONCLUSIONS:
In an international multisite POCUS cohort, LUS parameters had high discriminative accuracy. Ultrasound can be applied towards triage across a wide breadth of care settings during a pandemic.
Texto completo:
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article