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The Role of Genetics in Risk Stratification Strategy of Dilated Cardiomyopathy.
Xintarakou, Anastasia; Kariki, Ourania; Doundoulakis, Ioannis; Arsenos, Petros; Soulaidopoulos, Stergios; Laina, Aggeliki; Xydis, Panagiotis; Kordalis, Athanasios; Nakas, Nikolaos; Theofilou, Alexia; Vlachopoulos, Charalampos; Tsioufis, Konstantinos; Gatzoulis, Konstantinos A.
Afiliação
  • Xintarakou A; First Cardiology Department, National and Kapodistrian University of Athens, Hippokration General Hospital, 11527 Athens, Greece.
  • Kariki O; Department of Cardiology, Onassis Cardiac Surgery Center, Athens, 17674 Kallithea, Greece.
  • Doundoulakis I; First Cardiology Department, National and Kapodistrian University of Athens, Hippokration General Hospital, 11527 Athens, Greece.
  • Arsenos P; First Cardiology Department, National and Kapodistrian University of Athens, Hippokration General Hospital, 11527 Athens, Greece.
  • Soulaidopoulos S; First Cardiology Department, National and Kapodistrian University of Athens, Hippokration General Hospital, 11527 Athens, Greece.
  • Laina A; First Cardiology Department, National and Kapodistrian University of Athens, Hippokration General Hospital, 11527 Athens, Greece.
  • Xydis P; First Cardiology Department, National and Kapodistrian University of Athens, Hippokration General Hospital, 11527 Athens, Greece.
  • Kordalis A; First Cardiology Department, National and Kapodistrian University of Athens, Hippokration General Hospital, 11527 Athens, Greece.
  • Nakas N; Department of Cardiology, General Hospital of Nikaia-Piraeus "Agios Panteleimon", Piraeus, 18454 Nikaia, Greece.
  • Theofilou A; Department of Cardiology, General Hospital of Nikaia-Piraeus "Agios Panteleimon", Piraeus, 18454 Nikaia, Greece.
  • Vlachopoulos C; First Cardiology Department, National and Kapodistrian University of Athens, Hippokration General Hospital, 11527 Athens, Greece.
  • Tsioufis K; First Cardiology Department, National and Kapodistrian University of Athens, Hippokration General Hospital, 11527 Athens, Greece.
  • Gatzoulis KA; First Cardiology Department, National and Kapodistrian University of Athens, Hippokration General Hospital, 11527 Athens, Greece.
Rev Cardiovasc Med ; 23(9): 305, 2022 Sep.
Article em En | MEDLINE | ID: mdl-39077708
ABSTRACT
Dilated cardiomyopathy (DCM) is a heart disorder of diverse etiologies that affects millions of people worldwide, associated with increased mortality rate and high risk of sudden cardiac death. Patients with DCM are characterized by a wide range of clinical and pre-clinical phenotypes which are related with different outcomes. Dominant studies have failed to demonstrate the value of the left ventricular ejection fraction as the only indicator for patients' assessment and arrhythmic events prediction, thus making sudden cardiac death (SCD) risk stratification strategy improvement, more crucial than ever. The multifactorial two-step approach, examining non-invasive and invasive risk factors, represents an alternative process that enhances the accurate diagnosis and the individualization of patients' management. The role of genetic testing, regarding diagnosis and decision making, is of great importance, as pathogenic variants have been detected in several patients either they had a disease relative family history or not. At the same time there are specific genes mutations that have been associated with the prognosis of the disease. The aim of this review is to summarize the latest data regarding the genetic substrate of DCM and the value of genetic testing in patients' assessment and arrhythmic risk evaluation. Undoubtedly, the appropriate application of genetic testing and the thoughtful analysis of the results will contribute to the identification of patients who will receive major benefit from an implantable defibrillator as preventive treatment of SCD.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article