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Multiple cognition associated multimodal brain networks in major depressive disorder.
Yang, Xiao; Wang, Min; Liao, Qimeng; Zhao, Liansheng; Wei, Jinxue; Wang, Qiang; Sui, Jing; Qi, Shile; Ma, Xiaohong.
Afiliação
  • Yang X; Mental Health Center and Laboratory of Psychiatry, West China Hospital of Sichuan University, No. 28 Dianxin South Street, Wuhou District, Chengdu, China.
  • Wang M; Mental Health Center and Laboratory of Psychiatry, West China Hospital of Sichuan University, No. 28 Dianxin South Street, Wuhou District, Chengdu, China.
  • Liao Q; Mental Health Center and Laboratory of Psychiatry, West China Hospital of Sichuan University, No. 28 Dianxin South Street, Wuhou District, Chengdu, China.
  • Zhao L; Mental Health Center and Laboratory of Psychiatry, West China Hospital of Sichuan University, No. 28 Dianxin South Street, Wuhou District, Chengdu, China.
  • Wei J; Mental Health Center and Laboratory of Psychiatry, West China Hospital of Sichuan University, No. 28 Dianxin South Street, Wuhou District, Chengdu, China.
  • Wang Q; Mental Health Center and Laboratory of Psychiatry, West China Hospital of Sichuan University, No. 28 Dianxin South Street, Wuhou District, Chengdu, China.
  • Sui J; State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, No. 19, Xinjiekouwai Street, Haidian District, Beijing, China.
  • Qi S; College of Computer Science and Technology, Nanjing University of Aeronautics and Astronautics, No. 29 Yudao Street, Qinhuai District, Nanjing, China.
  • Ma X; Mental Health Center and Laboratory of Psychiatry, West China Hospital of Sichuan University, No. 28 Dianxin South Street, Wuhou District, Chengdu, China.
Cereb Cortex ; 34(7)2024 Jul 03.
Article em En | MEDLINE | ID: mdl-39077922
ABSTRACT
Major depressive disorder frequently leads to cognitive impairments, significantly affecting patients' quality of life. However, the neurobiological mechanisms underlying cognitive deficits remain unclear. This study aimed to explore multimodal imaging biomarkers associated with cognitive function in major depressive disorder. Five cognitive scores (sustained attention, visual recognition memory, pattern recognition memory, executive function, and working memory) were used as references to guide the fusion of gray matter volume and amplitude of the low frequency fluctuation. Social function was assessed after 2 yr. Linear regression analysis was performed to identify brain features that were associated with social function of patients with major depressive disorder. Finally, we included 131 major depressive disorder and 145 healthy controls. A multimodal frontal-insula-occipital network associated with sustained attention was found to be associated with social functioning in major depressive disorders. Analysis across different cognitive domains revealed that gray matter volume exhibited greater sensitivity to differences, while amplitude of the low frequency fluctuation consistently decreased in the right temporal-occipital-hippocampus circuit. The consistent functional changes across the 5 cognitive domains were related to symptom severity. Overall, these findings provide insights into biomarkers associated with multiple cognitive domains in major depressive disorder. These results may contribute to the development of effective treatment targeting cognitive deficits and social function.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encéfalo / Imageamento por Ressonância Magnética / Cognição / Transtorno Depressivo Maior Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encéfalo / Imageamento por Ressonância Magnética / Cognição / Transtorno Depressivo Maior Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2024 Tipo de documento: Article