Synthesis and bio-medical applications of multifunctional phosphorester cyclic amide anchored sterculia network.
Int J Biol Macromol
; : 134396, 2024 Aug 01.
Article
em En
| MEDLINE
| ID: mdl-39097063
ABSTRACT
The main focus of the present research is to design network hydrogels derived from natural polymers to promote a sustainable future. Multifunctional hydrogels were prepared by combining sterculia gum (SG), phosphorester -cyclic amide polymers for bio-medical applications including drug delivery (DD). The antibiotic drug ceftriaxone was incorporated into hydrogels to enhance wound healing potential. The surface morphology of copolymers was investigated by using FESEM and AFM techniques. FTIR and 13C NMR spectroscopic techniques provided insight into the formation of network structures. In FTIR analysis, distinctive bands were identified at 1649â¯cm-1 attributed to CO stretching of the cyclic amide of PVP, at 1147â¯cm-1 and 974â¯cm-1 representing PO stretching and P-O-C of poly(BMEP), respectively. In the 13C NMR spectrum, a prominent peak at 63.272â¯ppm revealed the presence of (O-CH2) linkage of poly(BMEP). XRD demonstrated amorphous characteristics of hydrogels. The interactions of copolymer with blood, bio-membrane and encapsulated drug illustrated their biocompatibility, bio-adhesion and controlled DD properties. The dressings expressed a hemolytic index value of 2.58⯱â¯0.03â¯%. The hydrogels exhibited mucoadhesive character, revealed from the adhesion force of 50.0⯱â¯5 mN needed to separate polymer dressing from the mucosa. Dressings exhibited antioxidant properties and displayed 33.73⯱â¯0.3â¯% radical scavenging in the DPPH assay. Protein adsorption test of copolymer illustrated 9.48⯱â¯0.970â¯% of albumin adsorption. The tensile strength of the dressing was found 0.54⯱â¯0.03â¯Nâ¯mm-2 while the burst strength 9.92⯱â¯0.27â¯N was observed. The sustained release of the drug was provided by supra-molecular interactions. Drug release followed a non-Fickian diffusion mechanism and the release profile was best described by the Higuchi kinetic model. Additionally, hydrogel dressings revealed permeability to H2O vapors and O2 and antimicrobial activity. These findings suggest the suitability of sterculia gum-based hydrogels for DD uses.
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01-internacional
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MEDLINE
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article