Additive Effects of Esaxerenone, a Nonsteroidal Mineralocorticoid Receptor Blocker, on Cardioplegic Arrest in Rat Hearts.
Ann Thorac Cardiovasc Surg
; 30(1)2024.
Article
em En
| MEDLINE
| ID: mdl-39098025
ABSTRACT
PURPOSE:
Esaxerenone, a mineralocorticoid receptor blocker, attenuates global ischemia-induced myocardial damage and coronary endothelial dysfunction. This study aimed to determine whether esaxerenone exerted cardioprotective effects against cardioplegic arrest in Wistar rat hearts.METHODS:
Isolated male Wistar rat hearts aerobically perfused via the Langendorff method for 20 min were randomly allocated to the Control (n = 6; perfused for an additional 10 min and subjected to no treatment) or Esax (n = 6; perfused with 0.1 µmol/L esaxerenone in perfusate for 10 min before ischemia) groups. Hearts in both groups were perfused with St. Thomas' Hospital No. 2 solution (STH2) for 2 min and subjected to 28 min of global ischemia. The recovery of left ventricular developed pressure (LVDP) and total troponin T leakage were measured after reperfusion.RESULTS:
The final recovery of LVDP (expressed as a percentage of pre-ischemic value) in the Control and Esax groups was 50.8 ± 3.5% and 62.1 ± 5.6%, respectively (p <0.05, Esax vs. Control). The total troponin T leakage in the Control and Esax groups was 138.8 ± 18.5 ng/g heart wt and 74.3 ± 18.6 ng/g heart wt, respectively (p <0.05, Esax vs. Control).CONCLUSION:
The administration of esaxerenone before cardioplegic arrest enhanced the cardioprotective effect exerted by STH2.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sulfonas
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Traumatismo por Reperfusão Miocárdica
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Função Ventricular Esquerda
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Ratos Wistar
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Pressão Ventricular
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Troponina T
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Modelos Animais de Doenças
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Antagonistas de Receptores de Mineralocorticoides
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Preparação de Coração Isolado
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Parada Cardíaca Induzida
Limite:
Animals
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article