Efficacy of colchicine and melatonin in the treatment of rat endometriosis model: An animal study.
J Reprod Immunol
; 165: 104294, 2024 Sep.
Article
em En
| MEDLINE
| ID: mdl-39106545
ABSTRACT
OBJECTIVE:
This study investigates the therapeutic effects of colchicine and melatonin on endometriotic implants in an experimentally created endometriosis model in rats. STUDYDESIGN:
Forty-four adult female Wistar albino rats weighing between 260 and 300â¯g, 8 weeks old, were selected for the study. The unilateral uterine horn of rats with a bicornuate uterus was excised for 1â¯cm, washed with sterile saline, incised longitudinally, and the endometrium was exposed. A 0.5*0.5â¯cm endometrial tissue sample taken with a scalpel was implanted with suturing (4/0 Vicryl) to the abdominal wall. Forty-four rats were divided into four groups. Group 1 was randomized as the endometriosis group (control), Group 2 as endometriosis + colchicine treatment, Group 3 as endometriosis + melatonin treatment, and Group 4 as the endometriosis + melatonin + colchicine treatment group. The colchicine (Sigma Chemical Co., St Louis, Missouri) group was administered orally at a dose of 0.1â¯mg/kg, and the Melatonin group orally at a dose of melatonin (20â¯mg/kg per day). Treatment continued daily for 30 days.RESULTS:
In the post-treatment focal diameter measurements, the endometrial focal diameter in the colchicine and colchicine + melatonin group was significantly lower than the control group (p=0.026). Bcl-2 levels of the colchicine group were lower than the control group and the melatonin group (p=0.021).CONCLUSION:
Colchicine and melatonin reduce adhesion to the peritoneal surface in ectopic endometrial cells. It also acts by increasing apoptosis and decreasing cell survival.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Colchicina
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Ratos Wistar
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Modelos Animais de Doenças
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Endometriose
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Endométrio
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Melatonina
Limite:
Animals
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Female
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Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article