Elevated blood pressure: a genetically determined risk factor for cerebral artery dissection.
Am J Hypertens
; 2024 Aug 07.
Article
em En
| MEDLINE
| ID: mdl-39110060
ABSTRACT
BACKGROUND:
We aim to investigate the potential causal link between blood pressure (BP) levels and cerebral artery dissection (CAD) risk employing a two-sample Mendelian randomization (TSMR) framework.METHODS:
Utilizing large-scale genome-wide association studies (GWAS)-retrieved data, we employed various MR techniques, including inverse variance weighted (IVW), MR-Egger regression, weighted median, and weighted mode, to ascertain BP's causal impact on CAD. The MR-Egger intercept was calculated to assess pleiotropy presence, determining heterogeneity by Cochran's Q statistic.RESULTS:
The findings highlighted a significant association between elevated systolic BP (SBP; IVW OR=3.09, 95% CI 1.11-8.61, p=0.031) and increased diastolic BP (DBP; IVW OR=2.17, 95% CI 1.14-6.21, p=0.023) with CAD risk. Sensitivity analyses reinforced the robustness and reliability of these results.CONCLUSIONS:
The results from this TSMR study suggest a causal link between high SBP and DBP and the increased likelihood of CAD, which provide genetic evidence for a reduced risk of CAD under blood pressure control.
Texto completo:
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article