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Serum Beta-Secretase 1 Activity Is a Potential Marker for the Differential Diagnosis between Alzheimer's Disease and Frontotemporal Dementia: A Pilot Study.
Saraceno, Claudia; Cervellati, Carlo; Trentini, Alessandro; Crescenti, Daniela; Longobardi, Antonio; Geviti, Andrea; Bonfiglio, Natale Salvatore; Bellini, Sonia; Nicsanu, Roland; Fostinelli, Silvia; Mola, Gianmarco; Riccetti, Raffaella; Moretti, Davide Vito; Zanetti, Orazio; Binetti, Giuliano; Zuliani, Giovanni; Ghidoni, Roberta.
Afiliação
  • Saraceno C; Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy.
  • Cervellati C; Department of Translational Medicine and for Romagna, University of Ferrara, 44121 Ferrara, Italy.
  • Trentini A; Department of Environmental and Prevention Sciences, University of Ferrara, 44121 Ferrara, Italy.
  • Crescenti D; Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy.
  • Longobardi A; Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy.
  • Geviti A; Service of Statistics, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy.
  • Bonfiglio NS; Service of Statistics, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy.
  • Bellini S; Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy.
  • Nicsanu R; Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy.
  • Fostinelli S; MAC-Memory Clinic and Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy.
  • Mola G; Department of Translational Medicine and for Romagna, University of Ferrara, 44121 Ferrara, Italy.
  • Riccetti R; Department of Environmental and Prevention Sciences, University of Ferrara, 44121 Ferrara, Italy.
  • Moretti DV; Alzheimer's Rehabilitation Operative Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy.
  • Zanetti O; Alzheimer's Research Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy.
  • Binetti G; MAC-Memory Clinic and Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy.
  • Zuliani G; Department of Translational Medicine and for Romagna, University of Ferrara, 44121 Ferrara, Italy.
  • Ghidoni R; Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy.
Int J Mol Sci ; 25(15)2024 Jul 30.
Article em En | MEDLINE | ID: mdl-39125924
ABSTRACT
Alzheimer's disease (AD) and frontotemporal dementia (FTD) are the two major neurodegenerative diseases causing dementia. Due to similar clinical phenotypes, differential diagnosis is challenging without specific biomarkers. Beta-site Amyloid Precursor Protein cleaving enzyme 1 (BACE1) is a ß-secretase pivotal in AD pathogenesis. In AD and mild cognitive impairment subjects, BACE1 activity is increased in brain/cerebrospinal fluid, and plasma levels appear to reflect those in the brain. In this study, we aim to evaluate serum BACE1 activity in FTD, since, to date, there is no evidence about its role. The serum of 30 FTD patients and 30 controls was analyzed to evaluate (i) BACE1 activity, using a fluorescent assay, and (ii) Glial Fibrillary Acid Protein (GFAP) and Neurofilament Light chain (NfL) levels, using a Simoa kit. As expected, a significant increase in GFAP and NfL levels was observed in FTD patients compared to controls. Serum BACE1 activity was not altered in FTD patients. A significant increase in serum BACE1 activity was shown in AD vs. FTD and controls. Our results support the hypothesis that serum BACE1 activity is a potential biomarker for the differential diagnosis between AD and FTD.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Biomarcadores / Ácido Aspártico Endopeptidases / Secretases da Proteína Precursora do Amiloide / Demência Frontotemporal / Doença de Alzheimer / Proteína Glial Fibrilar Ácida Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Biomarcadores / Ácido Aspártico Endopeptidases / Secretases da Proteína Precursora do Amiloide / Demência Frontotemporal / Doença de Alzheimer / Proteína Glial Fibrilar Ácida Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2024 Tipo de documento: Article