Steroid sensitivity of chronic uraemic and renal transplant patients measured by the antibody dependent cellular cytotoxicity reaction.
Haematologia (Budap)
; 18(4): 225-32, 1985.
Article
em En
| MEDLINE
| ID: mdl-3915294
ABSTRACT
The steroid (methylprednisolone) sensitivity of chronic uraemic and renal transplant patients was examined on the basis of the extent of inhibition of the antibody-dependent cellular cytotoxicity (ADCC) reaction, and via the effect on the ADCC capacity test (ADCC-C). Individuals with an inhibition of 30% or more were classified as steroid-sensitive. Immunopharmacological tests and the clinical picture showed 67%, 12 of the 18 renal transplant patients to be steroid-sensitive. In 92% of the cases the transplanted kidney was functioning well one year or more postoperatively. In 5 of the 6 steroid-resistant patients rejection necessitated removal of the transplanted kidney. The method is simple to perform and gives reproducible results, and appears suitable for application in clinical practice.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Uremia
/
Metilprednisolona
/
Transplante de Rim
/
Citotoxicidade Celular Dependente de Anticorpos
Tipo de estudo:
Diagnostic_studies
Limite:
Adolescent
/
Adult
/
Humans
/
Middle aged
Idioma:
En
Ano de publicação:
1985
Tipo de documento:
Article