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Rh(III)-Catalyzed C(sp3)-H Thiolation of 8-Methylquinolines Promoted by Benzoic Anhydride.
Yuan, Cheng-Kai; Pan, Yan-Nian; Wu, Yi-Fei; Sun, Wei-Yin; Meng, Zhen; Lu, Yi.
Afiliação
  • Yuan CK; Coordination Chemistry Institute, State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing National Laboratory of Microstructures, Collaborative Innovation Center of Advanced Micro-structures, Nanjing University, Nanjing 210023, China.
  • Pan YN; Coordination Chemistry Institute, State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing National Laboratory of Microstructures, Collaborative Innovation Center of Advanced Micro-structures, Nanjing University, Nanjing 210023, China.
  • Wu YF; Department of Chemistry, St Catherine's College, University of Oxford, Oxford OX1 3UJ, U.K.
  • Sun WY; Coordination Chemistry Institute, State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing National Laboratory of Microstructures, Collaborative Innovation Center of Advanced Micro-structures, Nanjing University, Nanjing 210023, China.
  • Meng Z; School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.
  • Lu Y; Coordination Chemistry Institute, State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing National Laboratory of Microstructures, Collaborative Innovation Center of Advanced Micro-structures, Nanjing University, Nanjing 210023, China.
J Org Chem ; 89(17): 11975-11982, 2024 Sep 06.
Article em En | MEDLINE | ID: mdl-39163632
ABSTRACT
Herein, we developed a ligand-promoted Rh(III)-catalyzed C(sp3)-H thiolation of 8-methylquinolines. The effect of ligands on improving the activity of the catalytic centers has been studied in detail and proven to be significant. Various substituents are well tolerated under this reaction condition to provide potential precursors for organic synthesis. The mechanistic study suggests that the reaction may proceed through a five-membered rhodacycle intermediate via thiolation twice.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2024 Tipo de documento: Article