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Lipidomics of sheep and goat Milk-based infant formulae during in vitro dynamic digestion.
Casula, Mattia; Manis, Cristina; Menard, Olivia; Tolle, Giulia; Cochet, Marie-Francoise; Dupont, Didier; Scano, Paola; Garau, Viviana; Caboni, Pierluigi.
Afiliação
  • Casula M; Department of Life and Environmental Sciences, University of Cagliari, 09124 Cagliari, Italy.
  • Manis C; Department of Life and Environmental Sciences, University of Cagliari, 09124 Cagliari, Italy.
  • Menard O; INRAE, L'Institut Agro, STLO, 35042, Rennes, France.
  • Tolle G; Department of Life and Environmental Sciences, University of Cagliari, 09124 Cagliari, Italy.
  • Cochet MF; INRAE, L'Institut Agro, STLO, 35042, Rennes, France.
  • Dupont D; INRAE, L'Institut Agro, STLO, 35042, Rennes, France.
  • Scano P; Department of Life and Environmental Sciences, University of Cagliari, 09124 Cagliari, Italy.
  • Garau V; Department of Life and Environmental Sciences, University of Cagliari, 09124 Cagliari, Italy.
  • Caboni P; Department of Life and Environmental Sciences, University of Cagliari, 09124 Cagliari, Italy. Electronic address: caboni@unica.it.
Food Chem ; 461: 140850, 2024 Dec 15.
Article em En | MEDLINE | ID: mdl-39173257
ABSTRACT
Lipid hydrolysis process during IF digestion, particularly the characterization of the lipidome and the resulting lipid breakdown products, has not been thoroughly investigated. This study aimed to compare the lipid hydrolysis profiles during the in vitro dynamic digestion of IFs made from whole sheep and goat milk. Using a lipidomics platform and multivariate statistical analysis, we observed changes in complex lipid levels during digestion. In the gastric compartment, we noted a progressive hydrolysis of triacylglycerols, phosphatidylcholines, and sphingomyelins. Conversely, lipolysis breakdown products like monoacylglycerols (e.g., MG(160), MG(180)), diacylglycerols, lysophosphatidylcholines (LPC 160, LPC 181, LPC 182), and free fatty acids increased in the intestinal compartment. The lipolysis trends were similar for both types of infant formulas, with long-chain fatty acid triglycerides (C > 46) exhibiting lower digestibility compared to medium-chain fatty acid triglycerides. Overall, these results indicate that sheep milk can be used as an ingredient in the manufacturing of IF.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cabras / Fórmulas Infantis / Leite / Digestão / Lipidômica Limite: Animals / Humans / Infant Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cabras / Fórmulas Infantis / Leite / Digestão / Lipidômica Limite: Animals / Humans / Infant Idioma: En Ano de publicação: 2024 Tipo de documento: Article