O-GlcNAcylation in tumorigenesis and its implications for cancer therapy.
J Biol Chem
; : 107709, 2024 Aug 21.
Article
em En
| MEDLINE
| ID: mdl-39178944
ABSTRACT
O-linked N-acetylglucosaminylation (O-GlcNAcylation) is a dynamic and reversible posttranslational modification that targets serine and threonine residues in a variety of proteins. Uridine diphospho-N-acetylglucosamine (UDP-GlcNAc), which is synthesized from glucose via the hexosamine biosynthesis pathway, is the major donor of this modification. O-GlcNAc transferase (OGT) is the sole enzyme that transfers GlcNAc onto protein substrates, while O-GlcNAcase (OGA) is responsible for removing this modification. O-GlcNAcylation plays an important role in tumorigenesis and progression through the modification of specific protein substrates. In this review, we discuss the tumor-related biological functions of O-GlcNAcylation and summarize the recent progress in the development of pharmaceutical options to manipulate the O-GlcNAcylation of specific proteins as potential anticancer therapies.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article