Action of gold thioglucose on pericapillary structures in the ventromedial hypothalamus.
J Pathol
; 129(2): 73-81, 1979 Oct.
Article
em En
| MEDLINE
| ID: mdl-392065
ABSTRACT
The administration of GTG to mice leads to death of all structures in a circumscribed area of the VMH as a result of loss of blood circulation. The loss of circulation is due to damage by GTG of neural processes adjacent to some of the capillaries in this area; damage to these processes leads to abnormal capillary permeability. Pericapillary damage occurs under conditions where capillary damage and consequent necrosis are prevented. Abnormal capillary permeability appears to follow release of a vasoactive substance from the damaged neural processes. Damage to the pericapillary neural processes by GTG is insulin-dependent and is counteracted by glucocorticoids.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Aurotioglucose
/
Ouro
/
Hipotálamo
/
Hipotálamo Médio
Limite:
Animals
Idioma:
En
Ano de publicação:
1979
Tipo de documento:
Article