Human immunoglobulin D: genomic sequence of the delta heavy chain.
Science
; 228(4700): 733-7, 1985 May 10.
Article
em En
| MEDLINE
| ID: mdl-3922054
ABSTRACT
The DNA coding for the human immunoglobulin D(IgD) heavy chain (delta, delta) has been sequenced including the membrane and secreted termini. Human delta, like that of the mouse, has a separate exon for the carboxyl terminus of the secreted form. This feature of human and mouse IgD distinguishes it from all other immunoglobulins regardless of species or class. The human gene is different from that of the mouse; it has three, rather than two, constant region domains; and its lengthy hinge is encoded by two exons rather than one. Except for the third constant region, the human and mouse genes are only distantly related.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Imunoglobulina D
/
Cadeias delta de Imunoglobulina
/
Cadeias Pesadas de Imunoglobulinas
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
1985
Tipo de documento:
Article