The yin and yang of the universal transcription factor NusG.
Curr Opin Microbiol
; 81: 102540, 2024 Oct.
Article
em En
| MEDLINE
| ID: mdl-39226817
ABSTRACT
RNA polymerase (RNAP), the central enzyme of transcription, intermittently pauses during the elongation stage of RNA synthesis. Pausing provides an opportunity for regulatory events such as nascent RNA folding or the recruitment of transregulators. NusG (Spt5 in eukaryotes and archaea) regulates RNAP pausing and is the only transcription factor conserved across all cellular life. NusG is a multifunctional protein its N-terminal domain (NGN) binds to RNAP, and its C-terminal KOW domain in bacteria interacts with transcription regulators such as ribosomes and termination factors. In Escherichia coli, NusG acts as an antipausing factor. However, recent studies have revealed that NusG has distinct transcriptional regulatory roles specific to bacterial clades with clinical implications. Here, we focus on NusG's dual roles in the regulation of pausing.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fatores de Alongamento de Peptídeos
/
Proteínas de Escherichia coli
/
Escherichia coli
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article