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Heparin-modified polyether ether ketone hollow fiber membrane with improved hemocompatibility and air permeability used for extracorporeal membrane oxygenation.
Li, Shangbo; Zhou, Shiyi; Qin, Xiangpu; Zhang, Shengchang; Zhao, X U; Wang, Kaixiang; Liu, Pengqing.
Afiliação
  • Li S; College of Materials and Chemistry and Chemical Engineering, Chengdu University of Technology, Chengdu 610059, China.
  • Zhou S; College of Materials and Chemistry and Chemical Engineering, Chengdu University of Technology, Chengdu 610059, China. Electronic address: zhoushiyi06@cdut.cn.
  • Qin X; College of Polymer Science & Engineering, Sichuan University, Chengdu 610065, China.
  • Zhang S; College of Polymer Science & Engineering, Sichuan University, Chengdu 610065, China.
  • Zhao XU; College of Polymer Science & Engineering, Sichuan University, Chengdu 610065, China.
  • Wang K; College of Polymer Science & Engineering, Sichuan University, Chengdu 610065, China.
  • Liu P; College of Polymer Science & Engineering, Sichuan University, Chengdu 610065, China.
Int J Biol Macromol ; 279(Pt 4): 135481, 2024 Nov.
Article em En | MEDLINE | ID: mdl-39251009
ABSTRACT
To expand the selection of raw material for fabricating extracorporeal membrane oxygenation (ECMO) and promote its application in lung disease therapy, polyether ether ketone hollow fiber membrane (PEEK-HFM) with designable pore characteristics, desired mechanical performances, and excellent biocompatibility was selected as the potential substitute for existing poly (4-methyl-1-pentene) hollow fiber membrane (PMP-HFM). To address the platelet adhesion and plasma leakage issues with PEEK-HFM, a natural anticoagulant heparin was grafted onto the surface using ultraviolet irradiation. Additionally, to explore the substitutability of the heparin layer while considering cost and scalability, a heparin-like layer composed of copolymers of acrylic acid and sodium p-styrenesulfonate was also constructed on the surface of PEEK-HFM Even though the successful grafting of heparin and heparin-like layers on the PEEK-HFM surface reduced the pore parameters, improvements in surface hydrophilicity also prevented the platelet-adhesion phenomenon and improved the anticoagulant behaviour, making it a viable alternative for commercial PMP-HFMs in ECMO production. Furthermore heparin-modified and heparin-like modified PEEK-HFMs demonstrated similar performance, indicating that synthetic layers can effectively replace natural heparin. This study holds practical and instructive significance for future research and the application of membranes in the development of oxygenators.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polietilenoglicóis / Polímeros / Benzofenonas / Heparina / Oxigenação por Membrana Extracorpórea / Membranas Artificiais Limite: Animals / Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polietilenoglicóis / Polímeros / Benzofenonas / Heparina / Oxigenação por Membrana Extracorpórea / Membranas Artificiais Limite: Animals / Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article