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Longitudinal genomic analysis of Neisseria gonorrhoeae transmission dynamics in Australia.
Taouk, Mona L; Taiaroa, George; Duchene, Sebastian; Low, Soo Jen; Higgs, Charlie K; Lee, Darren Y J; Pasricha, Shivani; Higgins, Nasra; Ingle, Danielle J; Howden, Benjamin P; Chen, Marcus Y; Fairley, Christopher K; Chow, Eric P F; Williamson, Deborah A.
Afiliação
  • Taouk ML; Department of Infectious Diseases, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
  • Taiaroa G; Victorian Infectious Diseases Reference Laboratory, The Royal Melbourne Hospital at The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
  • Duchene S; Department of Infectious Diseases, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
  • Low SJ; Victorian Infectious Diseases Reference Laboratory, The Royal Melbourne Hospital at The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
  • Higgs CK; Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
  • Lee DYJ; Department of Computational Biology, Institut Pasteur, Paris, France.
  • Pasricha S; Department of Infectious Diseases, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
  • Higgins N; Victorian Infectious Diseases Reference Laboratory, The Royal Melbourne Hospital at The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
  • Ingle DJ; Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
  • Howden BP; Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
  • Chen MY; Department of Infectious Diseases, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
  • Fairley CK; Infectious Diseases and Immune Defence Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Australia.
  • Chow EPF; Victorian Department of Health, Melbourne, VIC, Australia.
  • Williamson DA; Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Nat Commun ; 15(1): 8076, 2024 Sep 14.
Article em En | MEDLINE | ID: mdl-39277590
ABSTRACT
N. gonorrhoeae, which causes the sexually transmissible infection gonorrhoea, remains a significant public health threat globally, with challenges posed by increasing transmission and antimicrobial resistance (AMR). The COVID-19 pandemic introduced exceptional circumstances into communicable disease control, impacting the transmission of gonorrhoea and other infectious diseases. Through phylogenomic and phylodynamic analysis of 5881 N. gonorrhoeae genomes from Australia, we investigated N. gonorrhoeae transmission over five years, including a time period during the COVID-19 pandemic. Using a novel cgMLST-based genetic threshold, we demonstrate persistence of large N. gonorrhoeae genomic clusters over several years, with some persistent clusters associated with heterosexual transmission. We observed a decline in both N. gonorrhoeae transmission and genomic diversity during the COVID-19 pandemic, suggestive of an evolutionary bottleneck. The longitudinal, occult transmission of N. gonorrhoeae over many years further highlights the urgent need for improved diagnostic, treatment, and prevention strategies for gonorrhoea.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Filogenia / Gonorreia / Genoma Bacteriano / Genômica / COVID-19 / Neisseria gonorrhoeae Limite: Adult / Female / Humans / Male País/Região como assunto: Oceania Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Filogenia / Gonorreia / Genoma Bacteriano / Genômica / COVID-19 / Neisseria gonorrhoeae Limite: Adult / Female / Humans / Male País/Região como assunto: Oceania Idioma: En Ano de publicação: 2024 Tipo de documento: Article