Acyl Hydrazides as Insecticides: Synthesis, Biochemical, Structure-Activity Relationship Studies and Insecticidal Activity of some IGRs Analogues Against Spodoptera littorallis (Boisd.).

ABSTRACT

The exponential rise in pesticide resistance to conventional chemical pesticides is another major factor driving the development of novel insecticidal active agents. One approach to solving this problem is to investigate novel classes and environmentally safe insecticidal chemicals with a variety of modes of action. Among these techniques is the creation of novel tebufenozide derivatives. Tebufenozide belongs to the insect growth regulator class of insecticides and is regarded as one of the safest chemical insecticides ever. The toxicological and biochemical efficiency of each analog was assessed against the Spodoptera littoralis pest in both its second and fourth instar larvae. The bioassay results show that compound 7 was the most effective insecticidal agent, with LC50 values of 10.6.5 and 18.7 mg/L against S. littoralis larvae in their second and fourth instar larvae, respectively. Finally, it was shown how treatment with the LC50 of the examined substances affected the activity of many enzymes involved in the cuticle production of S. littoralis larvae in their fourth instar. From this study, it was concluded that Acyl hydrazide are helpful for the management of S. littoralis and will be an effective replacement for other synthetic insecticides.