Phenprocoumon metabolites in human plasma; characterization by HPLC and GC-MS.
Eur J Clin Pharmacol
; 29(5): 591-4, 1986.
Article
em En
| MEDLINE
| ID: mdl-3956564
ABSTRACT
Pooled plasma from patients receiving phenprocoumon anticoagulant therapy was extracted and the following substances were characterized phenprocoumon, and its 7-hydroxy,4'-hydroxy and 6-hydroxy derivatives; they were identified by HPLC and after methylation by quartz capillary GC-MS using the electron impact and selective ion monitoring modes. This is the first occasion when phenprocoumon metabolites have been identified in plasma; they were unconjugated and in much lower concentrations (43.2 and 2 ng/ml for the 7,4' and 6-hydroxy derivatives, respectively) than the original compound (2000 ng/ml).
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Femprocumona
/
4-Hidroxicumarinas
Limite:
Humans
Idioma:
En
Ano de publicação:
1986
Tipo de documento:
Article