Molecular analysis of the t(2;14) translocation of childhood chronic lymphocytic leukemia.
Science
; 232(4749): 491-4, 1986 Apr 25.
Article
em En
| MEDLINE
| ID: mdl-3961491
ABSTRACT
Two rare cases of chronic lymphocytic leukemia (CLL) in children have been studied; both are associated with a previously undescribed chromosomal translocation [t(2;14) (p13;q32)]. In one patient the translocation was reciprocal and the breakpoint on chromosome 14 occurred just 5' of the C gamma 2 region on the productive immunoglobulin heavy-chain allele. The breakpoint on chromosome 2 does not involve the K locus but lies within an uncharacterized region that coincides with the position of a constitutive fragile site that occurs within normal lymphocytes. Data on the second patient are consistent with these findings and suggest that these cases represent a rare but distinct subgroup of CLL's with a specific cytogenetic change.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Translocação Genética
/
Leucemia Linfoide
/
Cromossomos Humanos 1-3
/
Cromossomos Humanos 13-15
Limite:
Child
/
Humans
Idioma:
En
Ano de publicação:
1986
Tipo de documento:
Article