Ocular penetration of (125I)IVDU, a radiolabeled analogue of bromovinyldeoxyuridine.
Invest Ophthalmol Vis Sci
; 26(1): 45-9, 1985 Jan.
Article
em En
| MEDLINE
| ID: mdl-3967955
ABSTRACT
Following topical application of (125)IVDU, the radiolabeled analogue of bromovinyldeoxyuridine ([E]-5-[2-bromovinyl]-2'-deoxyuridine), as 0.5% or 0.3% eyedrops, to rabbits, (125I)IVDU appeared in the anterior chamber fluid at drug levels well above the minimum concentration (0.01 microgram/mL) required for inhibition of herpes simplex virus type 1 replication. These findings are consistent with the efficacy of 0.5% bromovinyldeoxyuridine eyedrops in the topical treatment of herpes simplex uveitis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ceratite Dendrítica
/
Idoxuridina
Limite:
Animals
Idioma:
En
Ano de publicação:
1985
Tipo de documento:
Article