Ocular signs in thiamine-deficient monkeys and in Wernicke's disease in humans.
Arch Ophthalmol
; 103(8): 1212-20, 1985 Aug.
Article
em En
| MEDLINE
| ID: mdl-4026652
ABSTRACT
Thiamine deficiency in the monkey is the animal counterpart of Wernicke's disease in humans. In the present study, thiamine deficiency was induced in 11 monkeys while three monkeys were given paired feedings supplemented by thiamine hydrochloride and three monkeys were maintained on regular chow. The typical clinical symptoms were apathy, inattention to peripheral stimuli, ataxia, ptosis, mydriasis progressing to pupillary areflexia, nystagmus, and ophthalmoparesis progressing to total ophthalmoplegia. With thiamine treatment, recovery was prompt and complete in mild to moderate cases but delayed and incomplete in severe cases. The animals were killed six or more months after discontinuance of the experiments to determine the chronic effects of treated thiamine deficiency. The significant abnormalities in the brain stem were symmetric gliosis and neuronal loss in the inferior colliculi, the regions of the third and sixth nerve nuclei, and the medial vestibular nuclei. White matter was characteristically spared. With the exception of the inferior colliculi, the target sites for neuropathologic changes were the centers for ocular motor control.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Deficiência de Tiamina
/
Encefalopatia de Wernicke
/
Encéfalo
/
Oftalmoplegia
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
Limite:
Animals
/
Humans
/
Male
Idioma:
En
Ano de publicação:
1985
Tipo de documento:
Article