Pharmacokinetic and therapeutic activity of polyinosinic-polycytidylic acid stabilized with poly-L-lysine in carboxymethylcellulose [poly(I,C)-LC].
J Biol Response Mod
; 4(6): 621-7, 1985 Dec.
Article
em En
| MEDLINE
| ID: mdl-4087033
Polyinosinic-polycytidylic acid stabilized with poly-L-lysine in carboxymethylcellulose [poly(I,C)-LC] significantly augmented natural killer (NK) cell activity in several tissues. Macrophage (M phi) tumoricidal activity was also markedly increased. Both effector cells were active for 9 days. Poly(I,C)-LC also increased effector cell response in vitro. Injections of poly(I,C)-LC resulted in elevated effector cell responses in four of five routes tested. Treatment with poly(I,C)-LC led to an earlier reconstitution of bone marrow cells, NK cell activity, and M phi effector cell activity in mice pretreated with cyclophosphamide (Cytoxan). Combined treatment of MBL-2 tumor cells with cytoreductive chemotherapy and poly(I,C)-LC resulted in an enhanced therapeutic response.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polilisina
/
Carboximetilcelulose Sódica
/
Poli I-C
/
Metilcelulose
Limite:
Animals
Idioma:
En
Ano de publicação:
1985
Tipo de documento:
Article