Failure of beta-adrenergic receptor blockade to prevent arrhythmias induced by sympathetic nerve stimulation.
Science
; 185(4145): 70-2, 1974 Jul 05.
Article
em En
| MEDLINE
| ID: mdl-4151754
ABSTRACT
Cardiac arrhythmias produced by electrical stimulation of the ventrolateral cardiac sympathetic nerve in dogs were not blocked by the combined administration of propranolol and practolol in amounts that completely blocked cardiac beta-adrenergic receptors. Blockade of cardiac alpha-adrenergic receptors, as well as cardiac cholinergic receptors, also had no influence on the arrhythmias. These results suggest that the adrenergic neuroeffector junction is fundamentally different from any hitherto described, differing perhaps in the neurotransmitter involved or in the nature of the receptor.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Arritmias Cardíacas
/
Sistema Nervoso Simpático
/
Transmissão Sináptica
/
Antagonistas Adrenérgicos beta
/
Coração
Tipo de estudo:
Etiology_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
1974
Tipo de documento:
Article