I-region genes are expressed on T and B lymphocytes. Studies of the mixed lymphocyte reaction (MLR).
J Exp Med
; 140(5): 1317-23, 1974 Nov 01.
Article
em En
| MEDLINE
| ID: mdl-4153771
ABSTRACT
Unidirectional mixed lymphocyte reactions (MLR) were performed between mouse strains differing for various segments within the H-2 complex. Thymocytes and purified lymph node T cells and B cells were used as stimulator cells. In three of five combinations studied, differing only within the I region, both T and B cells stimulated in the MLR. This suggests that the region codes for both T- and B-cell surface structures. However, if the difference was restricted to one I subregion (I-C), only T cells stimulated. This finding suggests that some of the I-region genes may be expressed either in T or in B cells.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Linfócitos B
/
Linfócitos T
/
Teste de Cultura Mista de Linfócitos
/
Genes
Limite:
Animals
Idioma:
En
Ano de publicação:
1974
Tipo de documento:
Article