[Genetic amniocentesis in early pregnancy]. / Genetische Amniozentese in der Frühschwangerschaft.

ABSTRACT

212 amniocentesis were performed at the Gynecological Clinic of the University Graz in cooperation with the Institute for Human Genetics of the same University from 1.7.1974 to 1.4.1978 for prenatal detection of genetic disorders or inherited disorders of metabolism. In 9 cases (4,2%) pathological results or special chromosomal aberrations were found. Five pregnancies (2,3%) had to be interrupted with prostaglandins. One case of Down-Syndrome ended by spontaneous abortion. Three women had a miscarriage following amniocentesis up to 6 weeks afterwards. In two cases (0,9%) a primary connection of puncture and loss of pregnancy could be documented. 4 cases (1,8%) suffered of amniotic fluid leakage after amniocentesis. Three patients delivered healthy term babies. This study demonstrates the high accuracy of the described diagnostic procedures.