Induction of endometrial peroxidase synthesis and secretion by estrogen and estrogen antagonist.
J Cell Biol
; 62(2): 449-59, 1974 Aug.
Article
em En
| MEDLINE
| ID: mdl-4426915
ABSTRACT
Synthesis of peroxidase was induced in the uterine epithelium of immature rats by multiple doses over a 24-96-h period of either 17 beta-estradiol, the estrogen-antagonist Parke-Davis CI-628, or a combination of estradiol plus antagonist. Endogenous peroxidase activity first appeared in the cisternae of the rough endoplasmic reticulum of surface epithelial and glandular cells within 24-48 after the initial injection. Uterine peroxidase activity was also visible in the cisternae of the Golgi apparatus, in Golgi-derived secretory granules, and within the uterine and glandular lumen. Some cells of the epithelium produced little or no peroxidase, even after 96 h. Whereas the antagonist appeared to induce synthesis and secretion of peroxidase, neither the antagonist alone nor the combined treatment (estradiol plus antagonist) reproduced the estradiol-mediated growth in organ size and increased lumen diameter.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peroxidases
/
Pirrolidinas
/
Endométrio
/
Estradiol
/
Antagonistas de Estrogênios
Limite:
Animals
Idioma:
En
Ano de publicação:
1974
Tipo de documento:
Article