Effect of DDS on phytohemagglutinin-induced lymphocyte transformation.
Int J Lepr Other Mycobact Dis
; 42(4): 412-15, 1974.
Article
em En
| MEDLINE
| ID: mdl-4477565
ABSTRACT
The influence of DDS on PHA-induced lymphocyte transformation was investigated in leukocyte cultures from two samples of healthy Caucasoid individuals. In one sample the sulfone-treated cultures differed from the controls in that they contained 0.4 mug/ml of other sample, the treated cultures contained DDS in concentrations of 4 mug/ml, 8 mug/ml and 16 mug/ml. The frequency of lymphocyte transformation induced by PHA was significantly reduced by DDS in all concentrations used. The data obtained are a strong indication that the plasma levels of dapsone among leprosy patients may contribute to the depression of the blastogenic capacity of their lymphocytes when stimulated by PHA.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ativação Linfocitária
/
Linfócitos
/
Dapsona
/
Lectinas
/
Hanseníase
Limite:
Adolescent
/
Adult
/
Animals
/
Female
/
Humans
/
Male
/
Newborn
Idioma:
En
Ano de publicação:
1974
Tipo de documento:
Article