Mode of action of chemotherapy in vivo on human acute leukemia. I. Daunomycin.
J Clin Invest
; 52(1): 126-33, 1973 Jan.
Article
em En
| MEDLINE
| ID: mdl-4509140
ABSTRACT
The leukocytes of 16 adult patients with acute myeloblastic leukemia were studied by autoradiographic methods to elucidate the mode of action of daunomycin. It was shown that daunomycin, at clinically useful doses, exhibits a cytolytic effect on all leukemic blasts whatever their cell-cycle phase. This cytolytic action affects, however, preferentially S-phase cells. It was shown also that blasts of patients less sensitive to daunomycin or receiving a lesser dose of the drug are temporarily blocked in G(2) phase (delayed mitosis) or in G(2) phase (prolonged generation time). Finally daunomycin appeared to hamper the passage of G(2)-blocked blasts from the bone marrow to the blood, while G(2)-phase cells crossed freely.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Leucemia Mieloide Aguda
/
Daunorrubicina
/
Leucócitos
Limite:
Humans
Idioma:
En
Ano de publicação:
1973
Tipo de documento:
Article