Selenium: biochemical role as a component of glutathione peroxidase.
Science
; 179(4073): 588-90, 1973 Feb 09.
Article
em En
| MEDLINE
| ID: mdl-4686466
ABSTRACT
When hemolyzates from erythrocytes of selenium-deficient rats were incubated in vitro in the presence of ascorbate or H(2)O(2), added glutathione failed to protect the hemoglobin from oxidative damage. This occurred because the erythrocytes were practically devoid of glutathione-peroxidase activity. Extensively purified preparations of glutathione peroxidase contained a large part of the (75)Se of erythrocytes labeled in vivo. Many of the nutritional effects of selenium can be explained by its role in glutathione peroxidase.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peroxidases
/
Selênio
/
Eritrócitos
Limite:
Animals
Idioma:
En
Ano de publicação:
1973
Tipo de documento:
Article