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Drug-induced change in the distribution of sulfonamides in the mother rat and its fetus.
Science ; 180(4089): 974-6, 1973 Jun 01.
Article em En | MEDLINE | ID: mdl-4706687
ABSTRACT
The distribution of a highly bound antibacterial sulfonamide was markedly altered in both the mother rat and its fetus by interfering with the binding of this drug to plasma protein in the mother. This effect was due to binding displacement, since the displacing agent had little or no effect on the distribution of another sulfonamide with very low binding to plasma protein.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sulfametoxipiridazina / Sulfanilamidas / Proteínas Sanguíneas / Sulfimpirazona / Troca Materno-Fetal Limite: Animals / Pregnancy Idioma: En Ano de publicação: 1973 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sulfametoxipiridazina / Sulfanilamidas / Proteínas Sanguíneas / Sulfimpirazona / Troca Materno-Fetal Limite: Animals / Pregnancy Idioma: En Ano de publicação: 1973 Tipo de documento: Article