Phase II study demonstrating failure of both a five-drug continuous-therapy regimen and a two-drug pulse-therapy regimen in the treatment of metastatic neuroblastoma: Southwest Oncology Group Study 822.
Cancer Treat Rep
; 63(8): 1383-4, 1979 Aug.
Article
em En
| MEDLINE
| ID: mdl-476711
ABSTRACT
Twenty-six children greater than 1 year of age with previously untreated stage IV neuroblastoma were randomized to receive either a five-drug regimen (prednisone, cyclophosphamide, actinomycin D, vincristine, and daunorubicin) or a two-drug regimen (cyclophosphamide and vincristine). Complete response rates were 6% and 9% for the five-drug and the two-drug regimens respectively. Partial response rates were 13% and 27% for the five-drug and the two-drug regimens respectively. The mean duration of the seven responses was 9 months, and all 26 patients had died within 2 years. Neither regimen was effective for long-term disease control in these children with neuroblastoma.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neuroblastoma
/
Antineoplásicos
Tipo de estudo:
Clinical_trials
Limite:
Humans
/
Infant
Idioma:
En
Ano de publicação:
1979
Tipo de documento:
Article