Induction of tumors in mice with the herbicide succinic acid 2,2-dimethylhydrazide.
Cancer Res
; 37(10): 3497-500, 1977 Oct.
Article
em En
| MEDLINE
| ID: mdl-561652
ABSTRACT
A solution of 2% succinic acid 2,2-dimethylhydrazide was given continuously in the drinking water of 6-week-old randomly bred albino mice for the remainder of their lives. The treatment gave rise to tumors of blood vessels, lungs, and kidneys. The tumor incidences in these tissues in the controls were 6, 18, and 0%, whereas in the treated groups the corresponding tumor incidences were 73, 73, and 5%. Light microscopic examination revealed typical angiomas and angiosarcomas of blood vessels, adenomas and adenocarcinomas of lungs, and adenomas of kidneys. The study thus demonstrates the tumorigenicity of the herbicide, succinic acid 2,2-dimethylhydrazide. Since the residues of this chemical occur in fruit, the human population is exposed to it. The environmental implication of this finding and the fact that the hydrazines as a class have tumorigenic properties are discussed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Succinatos
/
Carcinógenos
/
Dimetilidrazinas
/
Metilidrazinas
/
Neoplasias Experimentais
Limite:
Animals
Idioma:
En
Ano de publicação:
1977
Tipo de documento:
Article