Autoradiography with tritiated methotrexate and the cellular distribution of folate reductase.
Science
; 151(3717): 1528-30, 1966 Mar 25.
Article
em En
| MEDLINE
| ID: mdl-5909582
ABSTRACT
Bound methotrexate has been revealed by an autoradiographic procedure, presumed to introduce a method for cytochemical study of folate reductase. Preferential localization is seen in kidney proximal tubules, intestinal epithelium, and nuclei of parenchymal liver cells in mice. The extremely firm binding and prolonged retention of this drug should render it suitable as an inert label for the autoradiographic study of cell migrations and lifetimes.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Autorradiografia
/
Tetra-Hidrofolato Desidrogenase
/
Metotrexato
/
Intestino Delgado
/
Rim
/
Fígado
Limite:
Animals
Idioma:
En
Ano de publicação:
1966
Tipo de documento:
Article